The administration of hESC-MSC-IMRCs or hESC-MSC-IMRC-CM at d3, d7, and d14 post the first dose of BLM challenge led significant suppression of the BLM-induced expression of Tlr4, and p-NF-κB, TNF-α proteins (Figure 6a–c) and the production of IL-1β, TNF-α, and IL-6 (Figure 6d–f) in lungs of PF mice at an early stage of PF development, compared with that of mice challenged with BLM alone. This evidence concerns the gene TNF and pemphigus foliaceus.