The administration of hESC-MSC-IMRCs or hESC-MSC-IMRC-CM at d3, d7, and d14 post the first dose of BLM challenge led significant suppression of the BLM-induced expression of Tlr4, and p-NF-κB, TNF-α proteins (Figure 6a–c) and the production of IL-1β, TNF-α, and IL-6 (Figure 6d–f) in lungs of PF mice at an early stage of PF development, compared with that of mice challenged with BLM alone. The gene discussed is TLR4; the disease is pemphigus foliaceus.