HMOX1 and Bloom syndrome: Aligned with the decrease in MAD, molecular analysis revealed a significant inhibition of the expression of Nox4, Nrf2, Ho-1, and α-SMA in the lungs of BLM-challenged mice with hESC-MSC-IMRC-CM or hESC-MSC-IMRCs treatment compared to untreated BLM-injured mice (Figure 4g,h).