Two ongoing, multicenter, promising trials of PAK4 inhibitors are testing the safety of the orally bioavailable dual inhibitors ATG-019 and KPT-9274, targeting the PAK4 and PAK4 and NAMPT in advanced solid tumors, in non-Hodgkin’s lymphoma [123], and in relapsed acute myeloid leukemia [124]. The gene discussed is NAMPT; the disease is acute myeloid leukemia.