The presence of the pro-osteoclastogenic cytokines in the OI patients’ cultures is associated with an increase in the release of caspase-3 in the culture media following the treatment with 1 and 3 μmol/L neridronate (p = 0.008 and p = 0.0009, respectively). The gene discussed is CASP3; the disease is osteogenesis imperfecta.