They have proposed an integrative inflammatory hypothesis of schizophrenia that starts from the degradation of the inhibitory complex IκB and the activation by NFκB activity of pro-inflammatory enzymatic pathways through inducible nitric oxide synthase (iNOS) and isoform 2 of the enzyme cyclooxygenase-2 (COX-2). The gene discussed is NOS2; the disease is schizophrenia.