However, other components of the neuromuscular junction have also been implicated, e.g., muscle specific kinase (MuSK) in approximately 6% of MG patients [6,7], low-density lipoprotein receptor-related protein 4 (LRP4) in approximately 2% of MG patients [8,9], agrin and collagen Q [5,10]. The gene discussed is AGRN; the disease is myasthenia gravis.