Among AU cases, compared to those without GI symptoms those with GI symptoms had significantly higher innate immune cytokines, including; IFNα-2 levels (adjusted mean 86.574 (standard error 1.234) vs. 38.092 (1.241) pg/mL, p = 0.04); IL-1α levels (23.999 (1.496) vs. 5.028 (1.513) pg/mL, p = 0.04); TNFβ (21.672 (1.349) vs. 5.094 (1.358) pg/mL, p = 0.006); and, IL-15 (3.561 (1.405) vs. 0.690 (1.418) pg/mL, p = 0.006). The gene discussed is IFNA2; the disease is alopecia universalis congenita.