In this preliminary study, we found that children with AU and GI symptoms have elevated levels of innate cytokines IFNα, IL-1a, IL-15 and TNFβ, and adaptive cytokines IL-2, IL-4, IL-12 (p70), and IL-13, but decreased regulatory cytokine IL-10 compared with children with AU without GI symptoms. The gene discussed is IFNA1; the disease is alopecia universalis congenita.