The role of EVs is related to their cells of origin and this aspect is important in understanding how HMGB1 within EVs released by gastric cancer cells causes autophagy and pro-tumor activation of neutrophils via the HMGB1/TLR4/NF-κB axis; EVs containing HMGB1 released by bone marrow mesenchymal stem cells (BMSC) are modified, weakening the injury provoked by smoke inhalation. This evidence concerns the gene HMGB1 and neoplasm.