The aim of this study was to evaluate the diagnostic value of non-standard CSF biomarkers: interferon gamma (IFN-γ), interleukin 6 (IL6), NF-L, GFAP, CHI3L1, CXCL13, and OPN in patients suspected of MS according to the presence of T2-hyperintensive lesions on brain MRI. This evidence concerns the gene IL6 and myeloid sarcoma.