This diagnostic algorithm is based on a range of clinical signs indicative of WD, including the presence of Kayser-Fleischer’s rings, the presence and severity of neurological symptoms, reduced levels of ceruloplasmin, Coombs-negative hemolytic anemia, liver copper levels (absolute levels, or indicated by Rhodamine-staining), elevated urinary copper, and ATP7B mutations. The gene discussed is ATP7B; the disease is Wilson disease.