CAV1 and neoplasm: Since EVs carrying caveolin-1 are known to be involved in communication between different cell types within adipose tissue, such as endothelial cells and adipocytes [69], and considering recent studies showing that this protein is influencing tumor development or progression by controlling metabolism through glycolysis, fatty acid metabolism, or mitochondrial pathways [73], the role of caveolin-1 traveling within EVs deserves further analysis.