Indeed, MYC has been found to work during the transcription process not only as a chromatin binding factor, directly reorganizing the cancer genome, invading chromatin regulatory loci, such as promoters [3,19] and super enhancers [60] promoting—in the vast majority of cases—transcription activation, but also regulating many aspects linked to RNAPII activity such as release of transcriptional pausing, elongation of transcripts [13,16], and regulation of splicing [29]. This evidence concerns the gene MYC and cancer.