Moreover, recently a dysregulation of intracellular signaling pathways in mast cells and basophils leading to defect in cell function and the production of IgG autoantibodies directed against FcεRI or IgE on both mast cells and basophils or IgE autoantibodies against autoantigens like thyroid peroxidase, DNA and IL-24 have been demonstrated to be involved in urticaria pathogenesis [11]. Here, IGHE is linked to urticaria.