The international EAACI/GA2LEN/EuroGuiDerm/APAAACI guideline for the definition, classification, diagnosis, and management of urticaria [28], published in March 2022, reports that it is well known that causes of CSU include autoimmunity type I (CSU)aiTI, or “autoallergic CSU”; with IgE autoantibodies against autoantigens and type IIb autoimmunity (CSU)aiTIIb; with activating autoantibodies directed by mast cells. This evidence concerns the gene IGHE and urticaria.