More specifically, it has been described that the upregulation of Frizzled 8 (FZD8), a Wnt family receptor expressed in the EV-mRNA from mPC plasma samples, promotes invasion and stem cell-like phenotypes in vitro through the activation of Wnt/β-catenin signaling, promoting prostate cancer bone metastasis [60]. Here, FZD8 is linked to prostate cancer.