MAPK8 and brain ischemia: Among them is the recently synthesized JNK inhibitor 11H-indeno[1,2-b]quinoxalin-11-one oxime sodium salt (IQ-1S), whose ability to inhibit JNK has been shown in silico [19,25,26], and neuroprotective properties were demonstrated in models of cerebral ischemia [20,27,28].