F2 and hypertensive disorder: Interestingly, when compared to subjects with HTN, individuals diagnosed with MPNs display elevated concentrations of soluble p-selectin (p < 0.001), particularly if they harbor the JAK2V617F mutation (p = 0.006 between JAK2V617F-positive and JAK2V617F-negative cases), and D-dimers (p = 0.03), but similar soluble E-selectin, thrombin–antithrombin complexes, prothrombin fragments or antiphospholipid antibodies.