Further, there are no data to support or refute the claim that S1P receptor modulators are effective in the prophylaxis of NC-PASC, although it has been speculated that the neuroprotective and neuroregulatory properties of S1P are disrupted in COVID-19 infection, which could be a driver of long-term sequelae [135]. This evidence concerns the gene MBTPS1 and long COVID-19.