Further evidence for the pathologic role of CDC25C in LUAD comes from reports showing that downregulation of CDC25C mRNA in LUAD is associated with suppression of tumor cell proliferation [18] and that upregulation of CDC25C mRNA in the tumor is associated with acquisition of resistance to the anti-LC chemotherapeutic drugs cisplatin [19] and ganetespib [20]. This evidence concerns the gene CDC25C and neoplasm.