EDN1 and diabetes mellitus: Therefore, we assessed in our rat model of diabetes-induced LEAD femoral artery tissue, levels of AGEs, ET-1, iNOS, and eNOS, and blood levels of TNF-α and biomarkers of dyslipidemia (TG, CHOL, LDL-C, and HDL-C) and glycemia (glucose and HbA1c) with and without metformin treatment (Figure 2 and Table 1).