Taken together it was concluded that in the T2DM patients with hyperthyroidism, insulin resistance and elevated levels of thyroid hormones may have decisive role in the secretion of chemerin and resistin into the blood, while in the T2DM patients with hypothyroidism, the elevation of these adipocytokines was relatively independent of thyroid hormones and insulin action. The gene discussed is INS; the disease is hypothyroidism.