Further comparison of gene expressions between the two HCC cell classifications showed that 13 out of the 16 proto-oncogene targets (81%) were up-regulated in the S2/progenitor subtype, as compared to 10/16 (62%) in the S1/TGFβ-Wnt subtype (Figure 2B). The gene discussed is TGFB1; the disease is hepatocellular carcinoma.