According to gene ontology analysis, the regulated genes are involved in cholesterol and lipid metabolism (14 genes); apoptosis (5 genes); non-insulin-dependent diabetes mellitus (NIDDM) (5 genes); inflammatory responses (4 genes); insulin signalling (4 genes); carbohydrate metabolism (3 genes), and adipokine signalling (2 genes). The gene discussed is INS; the disease is diabetes mellitus.