MATR3 and nonpapillary renal cell carcinoma: Furthermore, a univariate Cox analysis of the combined two-markerset of MATR3-low/MRPL23-high was associated with poor survival prognosis (HR 4.14, 95%CI 2.71–6.31, p < 0.0001; Figure S6) and was a potent independent prognostic factor for ccRCC patients when examined in a multivariate analysis (HR 3.23, 95%CI 2.09–4.99, p < 0.0001; Table S2).