The pro-inflammatory cytokines and adipokines could, subsequently, drive insulin resistance, which has been proven to induce endothelial dysfunction, for example by activating the pro-atherogenic mitogen-activated protein kinase (MAPK) pathway in endothelial cells or by inducing nitric oxide (NO)-dependent vasodilatation [62]. The gene discussed is WNK2; the disease is endothelial dysfunction.