EPHA2 and melanoma: EphA2 expression is greater in metastatic cells than in initial melanoma cells, and Udayakumar et al. showed that eliminating EphA2 specifically from high-expressing melanoma cells caused substantial decreases in cell viability, colony formation, and migration in vitro and tumorigenicity in vivo, indicating EphA2 is a crucial survival factor in melanoma cells [95].