It has been experimentally demonstrated that other components of the HA signaling pathway, including hyaluronate synthases (HASs), hyaluronidase HYAL-1, and protein receptors, can also promote malignant behavior of tumor cells in vitro, in addition to tumor growth, metastatic capacity, and angiogenesis in animal models [23,24,25,26,27,28,29,30]. Here, HYAL1 is linked to neoplasm.