Among all four subtypes of epithelial OVCA at early stage, the population of intra-tumoral CISH-expressing cells was highest in ovarian high-grade serous carcinoma (HGSC) (mean ± SEM in 20,000 μm2 area, n = 5, p < 0.0001) as compared with other subtypes of epithelial OVCA including endometrioid (n = 3), mucinous (n = 3) and clear cell carcinoma (n = 3) at early stages (Figure 2D). Here, CISH is linked to clear cell adenocarcinoma.