Insulinoma is characterized by the uncontrolled secretion of insulin from β-cells, thereby causing a hypoglycemic syndrome and, in turn, adrenergic symptoms (palpitations and tremor), cholinergic symptoms (sweating, hunger, and/or paraesthesia) and neuro glycogenic symptoms (a wide variety of psychiatric and neurological manifestations) [55]. The gene discussed is INS; the disease is pancreatic insulinoma.