In microalbuminuric patients with T2DM, both angiotensin receptor antagonists (IRMA 2—Irbesartan Microalbuminuria Type 2 Diabetes Mellitus in Hypertensive Patients [25]; MARVAL—Micro Albuminuria Reduction with VALsartan Study Investigators [26]) and ACE inhibitors (ADVANCE) [22] decrease the risk of developing proteinuria. The gene discussed is ACE; the disease is type 2 diabetes mellitus.