TLR4 and neoplasm: TLR4, IL-6 and TNF-α expression was upregulated by palmitic acid in a neuroblastoma cell line in vitro and in vivo, TLR4-/- colorectal cancer (CRC) tumor growth was not affected by a diet enriched with palmitic acid, while wild-type CRC tumor growth was increased upon dietary intervention in mice [43,44].