Recent studies using chemical-induced colitis in an animal model have shown that the dietary supplementation of proanthocyanidins-rich extracts leads to strong protection against gut barrier dysfunctions [34,54] through modulating gut microbiota [64], inhibiting inflammatory responses, inhibiting NF-κB activation [61], reducing myeloperoxidase activity and increasing antioxidant enzyme activity [35]. Here, NFKB1 is linked to colitis.