To study whether the construct p14ARFmin-MDR1n-p14-tBID was active in vivo, lung cancer H1299 (mut N- Ras/null p53) and H460 (mut K-Ras/wt p53) cells were injected subcutaneously (1 × 106 cells with matrigel) into the hind flank of female athymic (nude) mice. Here, KRAS is linked to lung carcinoma.