In malignant cell lines BxPC-3 (pancreatic, wt Ras/mut p53), MB231 (breast, heterozygous mut/wt Ras and mut p53), and A431 (squamous cell carcinoma, wt Ras/mut p53), none of the constructs (Ad-p14ARFmin-p14-tBID ± MDR1n) induced significant apoptosis (2% to 4%) (Supplementary Figure S1B). Here, TP53 is linked to squamous cell carcinoma.