GATA4 and neoplasm: In addition, it has also been pointed out that in PanIN 2–3, an amplification of GATA6 is produced that promotes carcinogenesis and that it is maintained in the already established PDAC [18], which is in agreement with our observations, since in our series we did not detect differences in the expression of GATA4 or GATA6 between PanIN and tumor tissue [9].