PPARG and Anxiety: Increasing activity of the peroxisome proliferator-activated receptor-γ (PPARγ), an upstream positive regulator of adiponectin synthesis, through systemic administration of rosiglitazone (a PPARγ agonist) increases peripheral adiponectin levels and reduces antidepressant- and anxiety-like behavior in 24 h, which is not observed in adiponectin knockout mice [27].