In early MCI patients, the DST score increased (SMD = 1.01, 95% CI = [0.78, 1.42]), as presented by Hildreth and Ryan et al. [22,24]; DST reflects early arithmetic ability and, so, in early cognitive impairment patients, early intervention with PPAR-γ agonists may effectively better reverse the loss in arithmetic cognitive ability. The gene discussed is PPARG; the disease is Cognitive impairment.