Genes encoding ion receptors and channels, including voltage-gated calcium and chloride channels (CACNA1C, CLCN3) and the ligand-gated NMDA receptor subunit (GRIN2A), which is regulated by NMDA transmission and regulates NMDA receptor abundance, were cited as key factors in the development of schizophrenia [101]. This evidence concerns the gene CLCN3 and schizophrenia.