Golexanolone was also shown to be able to improve cognitive and motor function in a rat model of HE via decreasing peripheral inflammation and neuroinflammation, which are related to the TNFR1-glutaminase-GAT3 and TNFR1-CCL2-TrkB-KCC2 pathways [178]. The gene discussed is TNFRSF1A; the disease is hereditary elliptocytosis.