Following in vivo interaction of CAR T- and tumor cells, CAR T-cells liberate inflammatory cytokines (e.g., TNF-α and IFN-γ), leading to the hyperactivation of macrophages and the secretion of large amounts of IL-6 and IL-1β [36], which can be effectively abolished by the use of corticosteroids. This evidence concerns the gene IL6 and neoplasm.