Treatment of SCD mice with D3T (3H-1,2-dithiole-3-thione), an activator of nuclear-factor erythroid 2 like 2 (NRF2), which controls HMOX1 expression, reduced lethality in a model of heme-induced ACS in SS mice [37]. Here, NFE2L2 is linked to Schnyder corneal dystrophy.