In our model, key AD biomarkers are reproduced, including TARC/CCL17, MDC/CCL22, and MCP-4/CCL-13; of note, biomarkers derived from epithelia or the endothelium (C-TACK/CCL27 and Eotaxin-3/CCL26) were not reproduced in our model due to a lack of endothelium/epithelium. The gene discussed is CCL22; the disease is Alzheimer disease.