To study etiologic factors relevant to adult AD disease, we established a simple in vitro PBMC-derived model, as illustrated in Figure 2A. Skin tissue-derived signals may be key to the Th2 cell pathology associated with AD; in particular, there is strong evidence for both TSLP and the S. aureus-derived superantigen SEB in disease [51]. The gene discussed is SETBP1; the disease is Alzheimer disease.