MTOR and diabetic neuropathy: Nevertheless, both (i) the in vitro western blot analysis of the phosphorylation of mTOR and a downstream protein, S6, showing a decreased expression after 5-HT6 receptor inverse agonists application and (ii) the behavioral experiment conducted with intrathecal administration of the peptide Tat-VEPE designed to disrupt 5-HT6 receptor-mTOR interaction, indicate that mTOR, under the dependence of the 5-HT6 receptor, is likely involved in diabetic neuropathy-induced mechanical hyperalgesia.