As TSA and 5-aza-dC treatments increased IL-13Rα2 expression in prostate cancer cells grown in 3D culture, the effect of TSA or 5-aza-dC treatment on the sensitivity of prostate cancer cell spheroids to Pep-1-Phor21 was determined in vitro using the CellTox assay. This evidence concerns the gene IL13RA2 and prostate carcinoma.