NFE2L2 and Familial prostate cancer: Considering the protective roles of NRF2 in tissue injury and repair, Nfe2l2−/− mice are more susceptible to chemical- and radiation-induced tumorigenesis, and NRF2 activators were reported to reduce the burdens of several cancers, including liver cancer [91,92], colon cancer [93], breast cancer [94], prostate cancer [95], and bladder cancer [96].