In rats suffering from blast injury and hemorrhagic shock, Yang et al. [55] studied the roles of extracellular high-mobility group box 1 protein (HMGB1, also known as amphoterin) and its inhibitor, CX-01 (2-O,3-O-desulfated heparin), one of the minimally anticoagulant desulfated heparins, which does not cause heparin-induced thrombocytopenia but retains the anti-inflammatory properties. This evidence concerns the gene HMGB1 and Thrombocytopenia.