This may reflect the differences in (i) endosomal localization between ATP13A3 (early/recycling endosomes) and ATP13A2 (late endo/lysosomes) [11,12,13], (ii) cell type properties (endothelial versus neuroblastoma cells) and/or (iii) relative expression levels of ATP13A3 versus ATP13A2. The gene discussed is ATP13A3; the disease is neuroblastoma.