The interaction pairs via SPP1, RARRES2, NECTIN3, LGALS9, and LAMB1 showed increased signaling in the autophagy-high tumor cells, while SEMA3C, PTN, ICAM1, GAS6, and CSF1 showed decreased signaling compared with those in the autophagy-low tumor cells (Figure 4F). Here, SPP1 is linked to neoplasm.