Participants within the highest (T3) tertile of plasma NGAL concentrations demonstrated the highest rate of new-onset CKD (composite outcome: p = 0.029; based on eGFR < 60 mL/min/1.73 m2: p = 0.002), albeit not when solely defined by UAE > 30 mg/24-h (p = 0.483). This evidence concerns the gene LCN2 and chronic kidney disease.