When participants with eGFR < 65 mL/min/1.73 m2 at baseline (instead of <60 mL/min/1.73 m2) were excluded, the association between plasma NGAL and the risk of new-onset CKD remained similar, albeit lost statistical significance (HR per doubling 1.21 [0.95–1.53], p = 0.121). Here, LCN2 is linked to chronic kidney disease.