Furthermore, i.v. adoptive transfer of IPF/UIP primary fibroblasts in CB-17-SCID/bg mice induced PF in mice, but administration of a CCL21-blocking monoclonal antibody or an anti-CCR7 monoclonal antibody considerably decreased hydroxyproline levels and attenuated lung interstitial remodeling in these mice. Here, CCR7 is linked to idiopathic interstitial pneumonia.