The accumulation of collagen and increased numbers of intrapulmonary macrophages and fibroblasts in BLM-induced fibrosis are attenuated in CCL3-/- and CCR5-/- mice but not in CCR1-/- mice, demonstrating that locally produced CCL3 participates in BLM-induced immune cell recruitment and subsequent development of lung fibrosis via interactions with CCR5 [52]. The gene discussed is CCR5; the disease is fibrosis.