The main mediator of RAAS, angiotensin II (AngII), which acts by binding to either type 1 Ang II receptor (AT1R) or type 2 Ang II receptor (AT2R), has been associated with detrimental effects, generally promoting cardiac hypertrophy, vasoconstriction and inflammation, or with beneficial effects, including anti-inflammatory and cardio-protective effects, respectively. The gene discussed is AGT; the disease is cardiac hypertrophy.