For instance, the anti-cancer properties of (−)-epigallocatechin-3-gallate (EGCG), polyphenolic catechin found in green tea, have been demonstrated to inhibit numerous cancer types by directly restricting DNMT activity [31] that can lead to potentially reversing the epigenetic silencing of tumor suppressors such as CDKN2A and O6-methylguanine-DNA methyltransferase by cancer cells [32]. Here, CDKN2A is linked to cancer.