Another study found that, after a 6-month endurance training intervention in healthy subjects with a family history of T2DM, DNA methylation of genes including MEF2A, RUNX1, NDUFC2 and THADA involved in retinol metabolism and calcium-signaling pathways were decreased after exercise in skeletal muscle biopsies with known functions in muscle and T2DM. Here, RUNX1 is linked to type 2 diabetes mellitus.