NOS2 and neoplasm: Meanwhile, more recent studies communicated that escin inhibits metastasis by regulating the tumour microenvironment, for instance, by blocking ECM production, inhibiting hypoxia-inducible factor 1-alpha (HIF1α) targeted protein expression [54] and downregulating inducible nitric oxide synthase (iNOS) [48], RhoA and Rock proteins [49].